Longevity Aesthetics: A Conceptual Framework for Integrating Pro-Aging Medicine Into Surgical and Nonsurgical Practice

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

The prevailing paradigm in aesthetic medicine is the "antiaging" model, which focuses on correcting and/or reversing visible signs of aging. However, contemporary geroscience reconceptualizes aging as a malleable biological process driven by defined hallmarks, offering an opportunity to align aesthetic practice with the fundamental aging biology. This article explores the concept of "pro-aging" or "longevity aesthetics," a framework that prioritizes tissue function, resilience, and biological integrity alongside phenotypic improvement. The skin is presented as an accessible model organ that reflects key hallmarks of aging and their clinical manifestations. Although conventional aesthetic interventions effectively address structural changes, they often do not target upstream biological drivers of tissue aging. Within this framework, certain surgical and nonsurgical modalities may theoretically support tissue resilience through modulation of inflammation, collagen remodeling, and microvascular health. Importantly, some of these strategies, such as biostimulatory injectables including calcium hydroxylapatite and poly-L-lactic acid, as well as combination treatment approaches, are already integrated into clinical practice, whereas others remain in the translational or research domain. Emerging concepts such as multi-omics, defined as the integration of genomics, transcriptomics, pr

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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