The Management Growth Plate Injury in Animal Studies with Stem Cells Technique: Systematic Review
Sananta P., Isnansyah Y., Rosandi RD., Sugiarto MA.
Systematic Review, published in Acta Inform Med (2022) — summary generated from the PubMed abstract.
Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Systematic Review
- Journal
- Acta Inform Med (2022)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 35774837
- PMCID
- PMC9233467
- DOI
- 10.5455/aim.2022.30.121-124
- Citations
- 3
Abstract (original English)
Background Injury of growth plate may lead to serious complications such as bone bridge formation, deformity, growth disturbance, and limb length discrepancy. Stem cell therapy is one of the fields studied to mitigate this problem. There are various types and techniques which can be implemented. Objective This systematic review aims to review the most common techniques used in the experimental animal study about the application of stem cells to treat growth plate injury. Methods This study was conducted according to PRISMA guidelines. The following strategy was used. The terms used on the search engine were "stem cell growth plate injury" in PubMed database. A bibliometric evaluation was done on all the search results. Results The initial PubMed search yielded 74 results, but 5 articles were eliminated because they could not be accessed. From the remaining 69 articles, 50 were excluded after abstract and full-text review. Further, 7 articles were eliminated because they did not meet the inclusion criteria. Most studies are experimental animal studies, and there is no human trial regarding this matter. Conclusion There are still a few studies evaluating the application of stem cell in treating growth plate injuries, but the present results are generally satisfactory. Hopefully, clinical trials could be conducted in the near future.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.
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