SVF
Level D· Preclinical EvidenceAnimal Study

Marine Bioceramic Generation for Bone Tissue Regeneration: Sea Urchin (Echinometra mathaei) Exoskeleton-Derived Calcium Carbonate as a Precursor for Hydroxyapatite Synthesis, Incorporated into Chitosan Based-Hydrogel and

Jamshidizadeh S., Amrollahi Biuki N., Zarei M.

Animal Study on Back & Spine, published in Mar Biotechnol (NY) (2026) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Animal Study
Journal
Mar Biotechnol (NY) (2026)
Country
United States
Reported sample size
—
PMID
41609850
DOI
10.1007/s10126-025-10555-5

Abstract (original English)

The marine environment is a rich and diverse habitat, home to numerous organisms that serve as valuable sources of biological and pharmacological compounds. The skeletal structures of many marine invertebrates represent precursors for calcium phosphate (CaP) bioceramics. This study demonstrates hydroxyapatite (HA) synthesis from sea urchin (Echinometra mathaei) shell and spine, a sustainable CaCO₃ source. FTIR and XRD analysis revealed the presence of characteristic peaks associated with hydroxyapatite. SEM-EDS observations indicated that synthesis parameters determined the calcium to phosphorus ratio (Ca/P) and morphology of the derived calcium phosphate bioceramic. HA-based hydrogels play an important role in bone tissue engineering due to their high biocompatibility. The hydrogels were formulated as follows: a control group of oxidized carboxymethyl chitosan/cellulose (O-CMC/CEL), a composite group with commercial hydroxyapatite (O-CMC/CEL/HA), and two experimental composite groups containing HA synthesized from sea urchin spine (O-CMC/CEL/HA (spine-derived)) and shell (O-CMC/CEL/HA (shell-derived)). Four groups of hydrogels melded on 3D print frames to evaluate the osteogenic differentiation of human adipose-derived mesenchymal stem cells (ADSCs). SEM, FTIR, water contact angle, swelling rate, and live/dead assay results indicated that the porous composite hydrogels possess

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is preclinical work; animal or laboratory results cannot be applied to humans.

Evidence level

Evidence comes from animal or laboratory studies and has not been confirmed in humans.

How we grade evidence
AnimalsChitosanSea UrchinsCalcium CarbonateOsteogenesisHydrogelsDurapatiteCell DifferentiationTissue ScaffoldsPrinting, Three-Dimensional
Back & Spine
View on PubMedDOI

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