Matched Analysis of Circulating and Adipose Tissue SIRT1 Protein Level in Human Obesity
Salvatori L., Megiorni F., Baldazzi GM., Ventimiglia V., Gangitano E., Watanabe M.
Cohort Study, published in Nutrients (2026) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Cohort Study
- Journal
- Nutrients (2026)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 42075052
- PMCID
- PMC13118923
- DOI
- 10.3390/nu18081239
- Citations
- 1
Abstract (original English)
Background/Objectives : Mammalian sirtuins (SIRTs) are evolutionarily conserved proteins that are epigenetically involved in biological processes such as metabolism and longevity. SIRT1 expression is reduced in metabolic disorders and in complicated diseases such as obesity. However, whether the SIRT1 level in subcutaneous adipose tissue (SAT) matches with its circulating form in obesity is unknown. The aim of our study is to evaluate SIRT1 derived from SAT and plasma of the same subject in individuals with and without obesity to assess whether plasma measurements may provide clinically significant information. Methods : Eleven subjects with obesity (BMI ≥ 30 kg/m 2 ) and six controls without the disease (BMI 2 ) were enrolled, and SIRT1 was measured in SAT and plasma by ELISA. Anthropometric parameters, glycemia and transaminases were also assessed. Results : Patients with obesity showed similar levels of SIRT1 in SAT and plasma (1.28 ± 0.45 and 1.9 ± 0.25 ng/mL, respectively, p = 0.243). Patients without obesity showed higher SIRT1 levels in SAT than in plasma (4.19 ± 1.33 and 1.06 ± 0.12 ng/mL, respectively, p = 0.039). An inverse correlation between SAT-derived SIRT1 and BMI was found ( r = -0.632, p = 0.007). Conclusions : In this pilot study, our results show that the plasma SIRT1 levels substantially reflect those of SAT in patients with obesity. Given the metabolic role
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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