Mechanical and Biological Characterization of PMMA/Al 2 O 3 Composites for Dental Implant Abutments
Roato I., Genova T., Duraccio D., Ruffinatti FA., Zanin Venturini D., Di Maro M.
Laboratory Study, published in Polymers (Basel) (2023) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Polymers (Basel) (2023)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 37571080
- PMCID
- PMC10421041
- DOI
- 10.3390/polym15153186
- Citations
- 3
Abstract (original English)
The mechanical and biological behaviors of PMMA/Al 2 O 3 composites incorporating 30 wt.%, 40 wt.%, and 50 wt.% of Al 2 O 3 were thoroughly characterized as regards to their possible application in implant-supported prostheses. The Al 2 O 3 particles accounted for an increase in the flexural modulus of PMMA. The highest value was recorded for the composite containing 40 wt.% Al 2 O 3 (4.50 GPa), which was about 18% higher than that of its unfilled counterpart (3.86 GPa). The Al 2 O 3 particles caused a decrease in the flexural strength of the composites, due to the presence of filler aggregates and voids, though it was still satisfactory for the intended application. The roughness (Ra) and water contact angle had the same trend, ranging from 1.94 µm and 77.2° for unfilled PMMA to 2.45 µm and 105.8° for the composite containing the highest alumina loading, respectively, hence influencing both the protein adsorption and cell adhesion. No cytotoxic effects were found, confirming that all the specimens are biocompatible and capable of sustaining cell growth and proliferation, without remarkable differences at 24 and 48 h. Finally, Al 2 O 3 was able to cause strong cell responses (cell orientation), thus guiding the tissue formation in contact with the composite itself and not enhancing its osteoconductive properties, supporting the PMMA composite's usage in the envisaged applicatio
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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