Mechanical loading regulates osteogenic differentiation and bone formation by modulating non-coding RNAs
Deng H., Wan D.
Narrative Review, published in PeerJ (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- PeerJ (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40386232
- PMCID
- PMC12083469
- DOI
- 10.7717/peerj.19310
- Citations
- 1
Abstract (original English)
Bone tissue is highly responsive to mechanical stimuli, with mechanical loading serving as a crucial regulator of bone formation and resorption. The cellular transduction of mechanical loading involves intricate mechanisms, prominently featuring non-coding RNAs (ncRNAs). Various ncRNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), collaboratively regulate pathways involved in bone formation under mechanical loading. This article elucidates the mechanisms by which mechanical loading influences bone formation through ncRNAs, summarizing key ncRNAs and their regulatory pathways. Aimed at researchers and clinicians in molecular biology, orthopedics, and regenerative medicine, this study provides a theoretical foundation for the future application of mechanical loading to regulate osteogenic differentiation and offers insights into treating diseases associated with abnormal bone formation.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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