Mechanisms of obesity in the development of breast cancer.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Preclinical models and clinical retrospective data indicate that obesity is associated with a significant increase in the incidence, severity, and mortality from different types of cancer, including postmenopausal breast cancer. As discussed in the present review, both soluble factors and cellular players are involved in the mechanisms promoting local and metastatic breast cancer progression by adipose tissue. As the incidence of obesity is increasing worldwide, there is an urgent need for adequate preclinical models and preclinical and clinical studies designed to investigate how to inhibit the tumor-promoting activity of the adipose tissue.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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