SVF
Level A· Stronger Clinical EvidenceSystematic Review

Mesenchymal Stem Cell Levels of Human Spinal Tissues.

Harris L., Vangsness CT.

Systematic Review on Ligament Injury, Disc Degeneration, published in Spine (Phila Pa 1976) (2018) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Systematic Review
Journal
Spine (Phila Pa 1976) (2018)
Country
United States
Reported sample size
—
PMID
28885289
DOI
10.1097/BRS.0000000000002401

Abstract (original English)

Systematic review. The aim of this study was to investigate, quantify, compare, and compile the various mesenchymal stem cell (MSC) tissue sources within human spinal tissues to act as a compendium for clinical and research application. Recent years have seen a dramatic increase in academic and clinical understanding of human MSCs. Previously limited to cells isolated from bone marrow, the past decade has illicited the characterization and isolation of human MSCs from adipose, bone marrow, synovium, muscle, periosteum, peripheral blood, umbilical cord, placenta, and numerous other tissues. As researchers explore practical applications of cells in these tissues, the absolute levels of MSCs in specific spinal tissue will be critical to guide future research. The PubMED, MEDLINE, EMBASE, and Cochrane databases were searched for articles relating to the harvest, characterization, isolation, and quantification of human MSCs from spinal tissues. Selected articles were examined for relevant data, categorized according to type of spinal tissue, and when possible, standardized to facilitate comparisons between sites. Human MSC levels varied widely between spinal tissues. Yields for intervertebral disc demonstrated roughly 5% of viable cells to be positive for MSC surface markers. Cartilage endplate cells yielded 18,500 to 61,875 cells/0.8 mm thick sample of cartilage end plate. Ligament

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

How we grade evidence
AnimalsBone MarrowCell DifferentiationHumansIntervertebral DiscLigamentum FlavumMesenchymal Stem Cell TransplantationMesenchymal Stem CellsPeriosteumSpinal Cord
Face & SkinBack & SpineLigament InjuryDisc Degeneration
View on PubMedDOI

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