Mesenchymal stem cells injections in traumatology and orthopaedics: common practice or still a promising area with many uncertainties?

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Purpose To assess research directions of the Mesenchymal stem cells (MSCs) injections in traumatology and orthopaedics. Methods The study monitored the protocols of randomised controlled trials (RCTs) and systematic reviews (SRs) investigating mesenchymal stem cell (MSC) injections for various traumatological and orthopaedic conditions. Relevant RCT protocols were identified through searches of ClinicalTrials.gov, International Clinical Trials Registry Platform, EU Clinical Trials Register databases for RCTs and SRs were obtained from PROSPERO. The databases were searched from their inception to December 2023. Results A total of 449 clinical trials were identified. At the time of the study, 159 (35.4%) trials had been completed, and only 56 (12.5%) had published results in peer-reviewed journals. Data on clinical trial completion were normally distributed (p = 0.145). The duration for trial completion was 40.6 ± 26.5 months (range: 1 to 153 months). The most commonly investigated indications for MSCs injections were osteoarthritis of the hip and knee (37.6%) and spinal cord injuries (10.5%). The most frequent sources of MSCs were bone marrow (26.5%), adipose-derived (20.5%) and umbilical cord (15.4%). Reported MSCs concentrations varied widely, ranging from 0.5 × 10⁶ to 9.7 × 10⁸ cells. The most frequently used concentrations were 1 × 10⁷ (8.2%), 2 × 10⁷ (8.0%), 5 × 10⁷ (5.8%),

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

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