Mesenchymal Stem Cells - Sources and Clinical Applications.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

SUMMARY: Although mesenchymal stem cells (MSC) from different tissue sources share many characteristics and generally fulfill accepted criteria for MSC (plastic adherence, certain surface marker expression, and ability to differentiate into mesenchymal tissues), we are increasingly learning that they can be distinguished at the level of cytokine production and gene expression profiles. Their ability to differentiate into different tissues including endodermal and ectodermal lineages, also varies according to tissue origin. Importantly, MSC from fetal sources can undergo more cell divisions before they reach senescence than MSC from adult tissue such as bone marrow or adipose tissue. As we learn more about the differentiation and plasticity of MSC from different sources, health care providers in the future will use them tailored to different medical indications. Obwohl aus verschiedenen Geweben stammende mesenchymale Stammzellen (MSC) viele Gemeinsamkeiten aufweisen und im Allgemeinen die für MSC akzeptierten Kriterien erfüllen (plastische Adhäsion, Expression bestimmter Oberflächenmarker sowie Fähigkeit zur Differenzierung in mesenchymale Gewebe), wird immer klarer, dass sich MSC auf der Ebene der Zytokinproduktion und Genexpressionsprofile voneinander unterscheiden. Auch ihre Fähigkeit, in verschiedene Gewebe (inklusive endodermale und ektodermale Zelllinien) zu differenzieren

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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