Metabolically unhealthy adipose tissue is characterized by reductions in mitochondrial size and function
DeStephanis D., Long MR., Williams AG., Santiago M., Tonkin J., Stevens CM.
Animal Study with a reported sample of 44, published in Obesity (Silver Spring) (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Obesity (Silver Spring) (2025)
- Reported sample size
- 44
- Source database
- Europe PMC
- PMID
- 39948771
- PMCID
- PMC11897863
- DOI
- 10.1002/oby.24221
- Citations
- 2
Abstract (original English)
Objective Adipose function, not mass, underpins metabolic health. Lean and obese nonhuman primates (NHPs) naturally develop metabolic syndrome. Mitochondria-related measures in subcutaneous adipose tissue (SQ AT) and peripheral blood mononuclear cells may elucidate differences that transcend adiposity measures. Methods Obesity statuses ranged from very lean to severely obese ( 50%, n = 44), which were equivalent in healthy or unhealthy NHPs (metabolic syndrome score difference, p Results Unhealthy adipocytes had mitochondria one-half the size of healthy adipocytes (p Conclusions We conclude that targeting mitochondrial fusion processes would be a rational strategy to improve metabolic health, independent of total fat mass.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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