Methyltransferase-Like 3-Mediated N⁶-Methyladenosine Modification on RNAs: A Novel Perspective for the Pathogenesis and Treatment of Bone Diseases

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Osteoarthritis, osteoporosis, and osteosarcoma are prevalent osseous pathologies associated with the aberrant functionality of chondrocytes, osteoclasts, and osteoblasts, respectively. These conditions frequently exhibit therapeutic resistance and possess a high mortality risk, thus representing substantial health threats. To mitigate these concerns, it is imperative to investigate novel mechanistic insights. Methyltransferase-like 3 (METTL3) is pivotal in these disorders by modulating gene expression via N 6 -methyladenosine (m 6 A) modifications on RNA, thereby impacting cellular processes. Although considerable research has elucidated METTL3's involvement in these diseases, a systematic review is essential to summarise these findings and evaluate METTL3's significance. This review endeavours to aggregate and examine contemporary studies to elucidate METTL3's role in bone pathologies and its clinical implications. We propose that METTL3 constitutes a risk gene in these conditions by mediating m 6 A modifications on both mRNAs and non-coding RNAs, suggesting that METTL3 may serve as a critical diagnostic biomarker and therapeutic target. In conclusion, this review provides an extensive analysis of METTL3 and its correlation with osteoarthritis, osteoporosis, and osteosarcoma, offering valuable perspectives on extant research and serving as a valuable reference for researchers

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

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