Micro-Nano Composite System Combining Mesenchymal Stem Cells and Pirfenidone for Endometrial Regeneration via Microenvironment Remodeling.
Lin S., Shi H., Huang X., Chen X., Chen L., Zhan Q.
Animal Study, published in Adv Healthc Mater (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Adv Healthc Mater (2026)
- Country
- Germany
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 42478478
- DOI
- 10.1002/adhm.71466
Abstract (original English)
Endometrial injury remains a leading cause of female infertility, yet current clinical interventions exhibit limited regenerative efficacy. In this study, we developed a micro-nano composite system (G-H/ADSC@PDA/PFD) combining adipose-derived mesenchymal stem cell (ADSC)-laden double-network hydrogel (G-H/ADSC) microspheres with pirfenidone (PFD)-loaded polydopamine (PDA/PFD) nanoparticles to achieve synergistic stem cell and drug delivery. The microspheres were fabricated from gelatin methacryloyl (GelMA) and hyaluronic acid methacryloyl (HAMA) via droplet microfluidic technology, exhibiting favorable mechanical strength and cytocompatibility. They provide a 3D microenvironment that supports ADSC growth, proliferation, and paracrine secretion, thereby enhancing angiogenesis and modulating the inflammatory milieu. Moreover, the incorporated PDA/PFD nanoparticles enhance the adhesion of the composite system to the injured endometrial site, while efficiently scavenging reactive oxygen species. The sustained release of PFD downregulates TGF-β expression, inhibits collagen deposition and fibrotic progression, and further optimizes the regenerative niche for ADSCs. In a rat model of endometrial injury, the G-H/ADSC@PDA/PFD system significantly promoted endometrial regeneration, reduced fibrosis, restored the local microenvironment, and successfully restored fertility. This study int
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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