Microwave-assisted synthesis of lithium-bismuth co-doped hydroxyapatite with enhanced antimicrobial and biological performance.
Copur O., Evis Z., Gocmez H., Tuncer M., Altun S., Barbaro K.
Laboratory Study, published in J Mater Sci Mater Med (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- J Mater Sci Mater Med (2026)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 42165936
- DOI
- 10.1007/s10856-026-07067-6
Abstract (original English)
Hydroxyapatites (HA) co-doped with Li⁺ and Bi³⁺ ions were synthesized by a microwave-assisted wet precipitation method to improve their structural, biological, and antibacterial performances. Dual doping of Li⁺ and Bi³⁺ ions led to an increase in crystallinity and crystallite size compared to single doping, indicating successful incorporation of dopants into the HA lattice. Co-doping also resulted in minor lattice distortions without altering the phase purity of HA. Biological characterization using adipose-derived mesenchymal stromal cells revealed that Bi incorporation enhanced cell proliferation and osteogenic activity, whereas excessive Li addition caused partial cytotoxicity. Interestingly, Li/Bi co-doping balanced this effect, leading to improved cell viability and differentiation compared to single-doped samples. Moreover, Li and Bi substitutions imparted significant antimicrobial activity against E. coli, S. aureus, P. aeruginosa, E. faecalis, and C. albicans, demonstrating the dual bioactive and antimicrobial nature of the material. The combined influence of Li⁺ and Bi³⁺ ions effectively modified the crystallinity and biological response of HA, suggesting that Li-Bi co-doped HA is a promising candidate for multifunctional coatings and bone tissue engineering applications.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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