miR-130a-3p promotes fiber type transition and improves exercise tolerance in mice
Xing L., Zhou H., Deng H., Yao B., Luo J., Chen T.
Animal Study, published in Biol Res (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Biol Res (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41254818
- PMCID
- PMC12628931
- DOI
- 10.1186/s40659-025-00644-z
Abstract (original English)
BACKGROUND: Skeletal muscle plays various roles in physiological stress, such as movement, hormone secretion and oxidative metabolism. MicroRNA (miRNA) is involved in skeletal muscle development and fiber type transformation. Our previous studies have shown that miR-130a-3p is an important regulator of glycolipid metabolism and participates in the aerobic oxidation process. However, its potential impact on skeletal muscle development and muscle fiber type transformation by enhancement of aerobic metabolism of nutrients remains unexplored. METHODS: Mice with knockout and overexpression of miR-130a-3p were utilized to investigate its impact on mouse muscle development via assessments of body composition, metabolic activity in cages, and running performance. The influence of miR-130a-3p on muscle cell proliferation, differentiation, and fiber type was assessed following transfection of C2C12 cells. RESULTS: In this study, we found that miR-130a-3p overexpression significantly inhibited weight gain and fat content in mice, while promoting oxidative metabolism and improving exercise tolerance. Upregulation of miR-130a-3p in gastrocnemius (GAS) increased the expression of genes controlling cell proliferation, such as proliferating cell nuclear antigen (PCNA), cyclin D, and cyclin E, and decreased the protein expression of myosin heavy chain (MyHC), myogenic differentiation 1 (MyoD) a
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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