Mitochondria transplanted adipose-derived stem cells/decellularized adipose tissue hydrogel for adipose tissue regeneration.
Tang J., Han Y., Ren P., Xu L., Lei Z., Li J.
Animal Study, published in Mater Today Bio (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Mater Today Bio (2025)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 40893355
- PMCID
- PMC12391279
- DOI
- 10.1016/j.mtbio.2025.102193
- Citations
- 1
Abstract (original English)
Adipose tissue reconstruction is of significant importance for both cosmetic procedures and therapeutic interventions. Current clinical strategies, including autologous adipose tissue grafting and the application of synthetic materials, still have limitations. Decellularized adipose tissue (DAT) hydrogel in combination with adipose-derived stem cells (ADSCs), has emerged as a superior alternative, because of the abundant sources and inherent adipose regeneration capacity. Nevertheless, the therapeutic potential is constrained by the suboptimal functionality of ADSCs, due to the donor health status, long-term culture, and the post-transplantation environment in vivo. Mitochondria transplantation can enhance the proliferation, migration, differentiation, and pro-angiogenic ability of mesenchymal stem cells, thereby improving the tissue regeneration outcomes. In our research, we developed a novel soft tissue filler, mitochondria transplanted adipose-derived stem cells/decellularized adipose tissue (Mito-ADSCs/DAT) hydrogel. The constructive influence of the Mito-ADSCs/DAT hydrogel to angiogenesis and adipose tissue regeneration was validated in the nude mouse subcutaneous injection model. In vitro experiments and RNA-seq analysis were employed to elucidate the mechanism of Mito-ADSCs in improving adipose tissue regeneration. Although no significant enhancement in adipogenic differ
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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