Mitochondrial signatures of infant mesenchymal stem cells predict child adiposity: The Healthy Start Study.
Gyllenhammer LE., Keleher MR., Wood C., Yang IV., Friedman JE., Jansson T.
Animal Study with a reported sample of 134, published in Res Sq (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Res Sq (2026)
- Country
- United States
- Reported sample size
- 134
- Source database
- PubMed
- PMID
- 42183363
- DOI
- 10.21203/rs.3.rs-9476945/v1
Abstract (original English)
Although obesity risk is multifactorial, identification of molecular pathways at birth may reveal early-life susceptibility, guiding prevention and intervention efforts. We measured transcriptional and DNA methylation profiles of umbilical cord-derived mesenchymal stem cells (MSCs), which are progenitors for body composition ( e.g. , adipose, muscle), and tested associations with childhood adiposity over the first 4-6yr of life. Among 140 mother/child dyads enrolled in The Healthy Start Cohort Study, MSCs were isolated at birth and analyzed for their transcriptomic (RNAseq) and DNA methylation profile (Illumina EPIC). We measured newborn (24-72hrs after birth, n=134), infant (4-6mo, n=128), and early childhood (4-6yr, n=81) adiposity (%fat mass [%FM]) with air displacement plethysmography. A parallel in vitro adiposity phenotype was modeled as triglyceride accumulation during MSC adipogenesis. Prenatal obstetrics clinics at the University of Colorado Hospital in 2010-2014. Follow-up of women and children is ongoing. Singleton infants born to healthy women across the BMI spectrum. Newborn MSC transcriptome. Infant/childhood adiposity (%FM). 302 MSC transcripts were associated with %FM at birth, infancy and early childhood ( p =5, p =296 and p =1), respectively [false discovery rate, FDR<0.05]). Geneset Enrichment Analysis of transcriptome data revealed 670 pathways associated wi
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
How we grade evidenceBrowse all related research
Filter the research library by this study's title keywords, author, or publication year.