Modelling adipose tissue-cancer crosstalk: a three-dimensional perspective

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Innovative three-dimensional (3D) systems have become a focus of research due to their ability to better mimic cell-cell and cell-extracellular matrix interactions. Current advances in 3D modelling have the potential to transform pre-clinical research by providing a more biologically relevant recapitulation of the in vivo cell environment. Among the published 3D platforms there is a lack of adipose tissue and cancer complex models. Primarily thought to function in triglyceride storage, protection and heat production, adipose tissue is now recognised as a complex and dynamic endocrine organ that secretes factors such as free fatty acids and adipokines, which have been shown to play a role in carcinogenesis. Obesity, a major cause of adipose tissue dysfunction, has also been strongly linked to the development of several types of cancer. 3D model technologies offer an innovative way to investigate adipose tissue-cancer crosstalk by mimicking in vivo conditions. This review aims to present a perspective on the adipose tissue-cancer dynamics and provide an overview of the current 3D models used to reliably reproduce the adipose tissue-cancer interaction in vitro.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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