Modified peri-areolar mastopexy and fat grafting in complex breast ptosis: A randomized open-label controlled trial.

Several human studies show positive signals, while research methods and sample sizes continue to develop.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Complex breast ptosis may be caused by moderate to severe degrees of skin and glandular sagging associated with breast and nipple-areola complex (NAC) asymmetries and deformities. The use of traditional peri-areolar mastopexy (t-PM) with or without implants is limited only to mild or moderate breast ptosis. Objectives This study aimed to report the safety and efficacy of the modified peri-areolar mastopexy (m-PM) characterized by a vertical shift of the classical pattern with implants and fat grafting (FG) in complex breast ptosis and to evaluate the influence of breast and NAC asymmetries, breast, and chest deformities on aesthetics outcomes. Methods An open-label randomized controlled trial was performed. Forty women (study group - SG) affected by breast ptosis (moderate and severe), asymmetries, and deformities were treated with m-PM, implants, and FG, and their outcomes were compared with those in a control group (CG) (n = 35) treated with t-PM and implants. Aesthetic outcomes were evaluated using the patient's satisfaction grade, physician's assessment score, and visual Analog Scale (VAS). Results Overall, 75% (n = 30) of SG patients reported excellent results in terms of breast lift, shape, volume, NAC position, and scar quality after 12 months, whereas the CG reported the same outcomes in 60% (n = 21) of the cases. SG patients showed a vertical NAC shift and a

Evidence level

Several human studies show positive signals, while research methods and sample sizes continue to develop.

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