SVF
Level D· Preclinical EvidenceLaboratory Study

Modulating the biological response in vitro through hydrofluoric acid surface etching of ceria-stabilized zirconia/alumina/strontium hexa-aluminate composites.

Roato I., Mosca Balma A., Orrico C., Pedraza R., Genova T., Faga MG.

Laboratory Study on Face & Skin, published in Colloids Surf B Biointerfaces (2026) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Laboratory Study
Journal
Colloids Surf B Biointerfaces (2026)
Country
Netherlands
Reported sample size
—
PMID
41075763
DOI
10.1016/j.colsurfb.2025.115195

Abstract (original English)

Ceria-stabilized Zirconia/Alumina/Strontium hexa-Aluminate composites are promising candidates as metal-free dental implants. Isostatic pressed and sintered Ce 11 ZA 8 Sr 8 composites were prepared as regular disks starting from powders with composition 84 vol% ceria-stabilized zirconia (at 11 mol% ceria), 8 vol% α-Al 2 O 3 and 8 vol% SrAl 12 O 19 and they were either exposed to increasing etching treatment time (1 h, 2 h, 3 h) with hydrofluoric acid, or kept as a control, to determine the biological response elicited in human mesenchymal stem/stromal cells (ASCs), oral epithelial cells (SGs), and oral primary fibroblasts (PFs) cultured in vitro. FESEM microscopy and surface roughness assessment evidenced qualitatively and quantitatively an increasing roughness according to the etching time. Surface free energy was increased on roughened surfaces. The three cell types responded differently in terms of immediate adhesion (20 min), cell morphology (24 h), and proliferation up to 3 days. ASCs grew slowly, while SGs proliferated increasingly on all the surfaces, and PFs grew significantly more on the non-etched surface than on the etched surfaces (second and third day). ASCs were osteodifferentiated up to 4 weeks, studying gene expression and osteocalcin release. The interface characteristics of Ce 11 ZA 8 Sr 8 composites could be exploited to modulate cell response in vitro, with

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is preclinical work; animal or laboratory results cannot be applied to humans.

Evidence level

Evidence comes from animal or laboratory studies and has not been confirmed in humans.

How we grade evidence
ZirconiumHumansSurface PropertiesStrontiumHydrofluoric AcidCell ProliferationAluminum OxideMesenchymal Stem CellsCeriumFibroblasts
Face & Skin
View on PubMedDOI

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