[Morphological analysis of biomaterials obtained through micronization of adipose tissue].

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Abstract (original English)

To compare morphology of three autologous fat tissue fractions (milli-, micro-, and nanofat) obtained through mechanical micronization. Human adipose tissue harvested during aesthetic liposuction was fixed in glutaraldehyde and examined using light and transmission electron microscopy. Millifat preserved intact adipocytes, vascular structures, and extracellular matrix. Microfat showed partial tissue disintegration with increased number of vesicular elements. Nanofat is an amorphous emulsion devoid of cells but containing matrix and membrane fragments. Median particle sizes were 1.3 [0.8-1.7], 1.1 [0.8-1.4], and 0.4 [0.3-1.5] mm, respectively. There was a clear morphological gradient reflecting transition from preserved tissue to fragmented components. Micronization degree determines biological properties of the graft: millifat serves mainly as a volumetric filler, microfat combines volumetric and regenerative effects, nanofat demonstrates biomodulatory activity. These findings provide a morphological basis for standardized fat processing methods and development of automated devices for fat transferring. This is of practical significance in plastic and reconstructive surgery. Морфологическое сравнение трех фракций аутологичной жировой ткани: милли-, микро- и наножира, — полученных методом механической микронизации. Материалом служила жировая ткань, собранная при эстетической лип

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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