Morphology, differentiation and adhesion molecule expression changes of bone marrow mesenchymal stem cells from acute myeloid leukemia patients.
Chen Q., Yuan Y., Chen T.
Prospective Study, published in Mol Med Rep (2013) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Prospective Study
- Journal
- Mol Med Rep (2013)
- Country
- Greece
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 24220608
- DOI
- 10.3892/mmr.2013.1789
Abstract (original English)
Bone marrow mesenchymal stem cells (BMSCs) have been identified as an important component of the hematopoietic stem cell (HSC) niche, which is essential for the maintenance of HSCs. HSC niche alternation has been considered to be the main cause of acute myeloid leukemia (AML). However, little is known with regard to BMSC alteration in AML patients. BMSCs were collected from 10 AML patients and 13 controls in order to examine the morphology, differentiation and adhesion molecule expression changes. It was observed that primary BMSCs from AML patients exhibited aberrant morphologies compared with those from the controls. Prior to adipogenic differentiation, the mRNA and protein levels of the lipid marker gene lipoprotein lipase, from the BMSCs of AML patients, were significantly higher. lipid drops were present early during differentiation in the BMSCs of AML patients and exhibited greater numbers later. Following adipogenic differentiation, the mRNA level of E-cadherin in the BMSCs of AML patients was significantly lower than that identified in the BMSCs of the control groups. Following osteogenic induction, the mRNA level of E-cadherin in the BMSCs of AML patients was significantly higher than in the controls. Therefore BMSCs from the AML patients exhibited irregular morphology, tendency to pre-differentiate to adipocytes and different adhesion molecule expression following dif
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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