Morphometric effectiveness of calcium hydroxylapatite application in zygomatic and malar area on correction of nasolabial folds

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

This study aims to investigate the indirect effects of calcium hydroxylapatite (CaHA) injections in the zygomatic and malar regions on the healing of nasolabial folds (NLFs). Given the anatomical complexity and proximity of the nasolabial area, selecting appropriate techniques for CaHA applications is crucial to prevent potential complications. The study is designed to contribute insights into the safety and efficacy of injections, aiming to enhance patient outcomes and minimize risks in aesthetic applications. This retrospective single-center study analyzed the effectiveness of CaHA injections in the zygomatic and malar regions for correcting NLFs in 51 female participants aged between 30 and 55. Images from clinical archives were used, taken before the application and 6 months after the application. The primary outcomes were evaluated using Gabor filter analysis, Global Aesthetic Improvement Scale, and Wrinkle Severity Rating Scale, complemented by morphometric measurements using Image J 1.52a software. Measurements before and 6 months after the application revealed significant improvements in NLF length: from 2.59 ± 0.64 cm to 2.24 ± 0.53 cm on the right side and from 2.76 ± 0.81 cm to 2.59 ± 0.61 cm on the left side. This corresponds to an improvement of 13.51 % and 6.16%, respectively. Evaluations using the Wrinkle Severity Rating Scale, Global Aesthetic Improvement Scale

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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