MRI imaging versus histologic volumetric estimation of residual injection laryngoplasty material
Bowen AJ., San-Marina S., Hunter D., Voss S., Bartemes K., Macura S.
Laboratory Study with a reported sample of 8, published in Laryngoscope Investig Otolaryngol (2022) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Laryngoscope Investig Otolaryngol (2022)
- Reported sample size
- 8
- Source database
- Europe PMC
- PMID
- 35434315
- PMCID
- PMC9008163
- DOI
- 10.1002/lio2.744
- Citations
- 1
Abstract (original English)
Objectives To examine the degree of agreement between MRI and histologically generated volumetric measurements of residual injection laryngoplasty material. Methods Following left recurrent laryngeal nerve transection, rabbit vocal cords were injected with jellyfish collagen, Cymetra®, or Restylane®. Laryngeal tissue was harvested 4 or 12 weeks post injection followed by MRI imaging and histologic cross-sectioning. Two raters estimated the volume of remaining injection material in specimens within MRI and histologic axial cross sections. Wilcoxon signed rank tests were employed to detect gross differences between inter-rater measurements and between imaging modalities across time. Agreement between rater measurements and imaging (histology and MRI) was assessed using intra-class correlation coefficients. Results Data was available from 16 rabbits sacrificed at 4 weeks ( n = 8) and 12 weeks ( n = 8). Inter-rater testing of MRI imaging revealed no significant differences ( p > .05) between rater measurements across time points, and excellent agreement (0.93; 95% confidence interval 0.80-0.98) while histologically estimated volumes demonstrated a significant difference at 4 weeks ( p p p > .05). Overall, there is only moderate agreement between MRI and histology estimates (0.72; 95% confidence interval 0.22-0.90). Conclusions MRI imaging demonstrates good reliability and similar e
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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