MSC administration resolves experimental acute gout increasing specialized pro-resolving mediators synthesis through a super-induction of prostaglandin E 2 .

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

The resolution of inflammation is an active process triggered in the acute phase of inflammation and mainly directed by specialized pro-resolving mediators (SPMs). Modulating the inflammatory response in favor of resolution is a therapeutic strategy of enormous interest and value. Previous studies have shown that human adipose mesenchymal stem cells (MSCs) possess the ability to shorten the acute inflammatory response by hinting an early cyclooxygenase (COX)-2 induction. We studied the potential of MSC to accelerate the resolution of inflammation through the direct promotion of the local synthesis of SPMs, and the role of prostaglandin (PG) E 2 release in this process in a model of experimental acute arthritis. Gouty arthritis was induced in male New Zealand rabbits via intra-articular injection of monosodium urate (MSU) crystals. Human adipose-derived MSCs were administered systemically in a single dose. Synovial membrane levels of SPMs were measured by liquid chromatography-tandem mass spectrometry, PGE 2 and genes related to the pro-resolving and anti-inflammatory pathways were assessed. Employing THP-1-derived macrophages and human adipose-derived MSC co-cultures stimulated with MSU crystals, we elucidated the mechanisms associated to the induction of resolution by MSCs. MSC treatment enhanced the local release of a broad range of SPM precursors and active mediators in the

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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