Muscle Tissue Remodeling Following Intramuscular Fat Grafting: Structural and Transcriptomic Insights.
Mendanha M., Soares R., Luís C., Pedrosa SS., Ferreira C., Pinto-Ribeiro I.
Retrospective Study, published in Aesthet Surg J (2026) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Retrospective Study
- Journal
- Aesthet Surg J (2026)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 42330138
- DOI
- 10.1093/asj/sjag121
Abstract (original English)
Background Liposculpture with autologous fat grafting represents an advanced body contouring approach that enhances muscular definition and volume through selective extraction and anatomical redistribution of adipose tissue. While these procedures are primarily used for aesthetic refinement, emerging evidence suggests autologous fat transfer may also induce significant biological adaptations within grafted muscle. Objectives Evaluate the biological implications of intramuscular fat grafting. Methods A retrospective within-subject controlled study was conducted. One year postoperatively, paired biopsies were harvested from the fat-grafted muscle pectoralis major (MPM) and the untreated muscle vastus lateralis (MVL) in 7 male patients following liposculpture and intramuscular fat transfer using the Percutaneous Retrograde Intramuscular Echo-Guided Fat Grafting (PRIME-GRAFT) technique. Subsequent assessments were performed via histological and transcriptome analyses. Results Histological evaluation comparing treated MPM to untreated MVL one year following liposculpture and intramuscular fat grafting via PRIME-GRAFT technique demonstrated significant reduction in fibrosis and elevated glycogen concentrations within treated muscles. Reduced collagen deposition and elevated glycogen content findings are biologically associated with improved tissue composition. Microarray transcriptom
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • Without an adequate control group, treatment effects cannot be separated from other factors.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
How we grade evidenceBrowse all related research
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