Nano-curcumin potentiates antitumor immunity in prostate cancer via co-culture with adipose-derived mesenchymal stem cells.
Zeynali F., Tehran MH., Faraji F., Mahmoudi M., Tabasi NS., Ghoreyshi S.
Prospective Study, published in BMC Complement Med Ther (2025) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Prospective Study
- Journal
- BMC Complement Med Ther (2025)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41094465
- PMCID
- PMC12523222
- DOI
- 10.1186/s12906-025-05129-w
Abstract (original English)
Background Curcumin is a polyphenolic compound from Curcuma longa that exhibits immunoregulatory and anti-cancer properties. It is formulated as nano-curcumin. Mesenchymal stem cells (MSCs) also show anticancer effects and can potentially activate resting immune cells. This study investigates the combined effects of nano-curcumin and adipose-derived mesenchymal stem cells (ASCs) on peripheral blood mononuclear cells (PBMCs) isolated from prostate cancer (PCa) patients. Methods ASCs were isolated and characterized. PBMCs were isolated from patients and co-cultured with and without ASCs in the presence of different concentrations of nano-curcumin to examine cell survival using the MTT assay. Based on the results of the MTT assay, selected concentrations of nano-curcumin were used to investigate apoptosis and cell subpopulations of PBMCs in co-culture with ASCs using apoptosis assay and flow cytometry. Results Nano-curcumin increased PBMC survival at concentrations of 3, 6, 12, 25, and 50 µM in co-culture with ASCs. In the absence of ASCs, a significant increase in PBMC survival was observed at concentrations of 6, 12, 25, 50, and100 µM. Concentrations of 6 and 12 µM caused a significant reduction in apoptosis. A concentration of 12 µM increased the number of CD3 + CD4 + cells, and the number of CD3 + CD8 + cells increased at concentrations of 6 and 25 µM. At a concentration of 25
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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