Nanofibrous GelMA-Based Scaffolds Support Human Adipose-Derived Mesenchymal Stem/Stromal Cell Adhesion, Viability, and Growth.
Rivera L., Popov Pereira da Cunha MD., Sabbatella RJ., Del Veliz S., Abraham GA., Uhart M.
Laboratory Study, published in J Biomed Mater Res A (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- J Biomed Mater Res A (2025)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 40260738
- DOI
- 10.1002/jbm.a.37914
- Citations
- 1
Abstract (original English)
Drawing inspiration from the extracellular matrix (ECM), where fiber organization profoundly influences cell behavior, electrospun scaffolds have emerged as powerful tools for modulating cellular responses in vitro. While electrospinning enables the replication of ECM architecture, selecting suitable materials is paramount for effective cell adhesion and growth. In this study, we aimed to develop cost-effective scaffolds for human adipose-derived mesenchymal stromal cells (hAD-MSCs) using gelatin methacrylate (GelMA) blended with either polycaprolactone (PCL) or poly(ethylene glycol) dimethacrylate (PEGDMA). Through comparing randomly oriented and aligned fibers, we identified fiber direction as a critical factor in determining cell behavior. Surprisingly, we found that despite material hydrophobicity, the cells aligned with the fiber direction, highlighting the dominant influence of fiber alignment on cell spreading. This research underscores the importance of material selection and fiber orientation in engineering scaffolds for directing cell behavior in tissue regeneration applications.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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