Naringin Alleviates H 2 O 2 -Inhibited Osteogenic Differentiation of Human Adipose-Derived Stromal Cells via Wnt/ β -Catenin Signaling.

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Osteoporosis is an age-related systemic bone disease that places a heavy burden on patients and society. In this study, we aimed to investigate the effects of naringin (NAR) on the osteogenic differentiation of human adipose-derived stromal cells (ADSCs). The results demonstrated that NAR pretreatment effectively abated H 2 O 2 -induced cell death and ROS accumulation in ADSCs undergoing osteogenic differentiation (ADSCs-OD). In addition, we also observed that the impaired extracellular matrix mineralization and ALP activity in H 2 O 2 -stimulated ADSCs-OD were notably rescued by NAR pretreatment. Moreover, the effects of H 2 O 2 exposure on Wnt/ β -catenin signaling in ADSCs-OD were largely reversed by NAR pretreatment. Collectively, our findings indicated that NAR could protect ADSCs-OD against H 2 O 2 -inhibited osteogenic differentiation.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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