The Natural Defense: Anti-Aging Potential of Plant-Derived Substances and Technological Solutions Against Photoaging

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Photoaging is a multifactorial and progressive skin aging process primarily triggered by prolonged exposure to ultraviolet (UV) radiation. This condition leads to both structural and functional impairments in the skin, including the formation of wrinkles, loss of elasticity, pigmentation irregularities, and an elevated risk of skin malignancies. At the core of photoaging is the accumulation of reactive oxygen species (ROS), which generate oxidative stress, initiate chronic inflammation, cause DNA damage, and accelerate the breakdown of the extracellular matrix-largely through the activity of matrix metalloproteinases (MMPs). The review provides a comprehensive analysis of various natural substances, including antioxidants, anti-inflammatory agents, photoprotective compounds, and emerging regenerative treatments, based on in vitro and in vivo research. Special emphasis is placed on natural substances, including polyphenols, cannabinoids, carotenoids, retinoids, and vitamins, highlighting their potential in preventing and treating photoaging. This review aims to present a detailed, evidence-based overview of photoaging mechanisms and innovative approaches to mitigate its effects.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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