Needle gauge and length effects on human stem cell viability during injection: a comprehensive review
Habiba UE., Shamim S., Greene DL.
Narrative Review, published in Front Cell Dev Biol (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Front Cell Dev Biol (2026)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 42311508
- PMCID
- PMC13269218
- DOI
- 10.3389/fcell.2026.1845972
Abstract (original English)
The therapeutic efficacy of stem cell-based treatments depends critically on maintaining high cell viability through the injection process. Mechanical stress induced on cells during passage through injection needles represents a significant source of cell damage that can compromise therapeutic outcomes. This review examines the current understanding of how needle gauge (diameter) and length affect human stem cell viability, exploring the mechanical forces involved, empirical evidence across different stem cell types, and practical implications for clinical protocols. We analyze the competing demands of minimizing tissue trauma through smaller needles while preserving cell viability and provide evidence-based recommendations for optimizing injection parameters across various clinical applications.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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