Level D· Scientific groundwork from lab and animal studiesNarrative ReviewEurope PMCOpen access

Nerve Grafts in Breast Reconstruction: A Narrative Review

Shen Y., Zhang J., Liu Y., Cai H.

Narrative Review, published in Breast J (2025) — summary generated from the PubMed abstract.

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Level D· Scientific groundwork from lab and animal studiesEvidence level of this study

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
Read the A–D evidence level guide

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Narrative Review
Journal
Breast J (2025)
Reported sample size
—
Source database
Europe PMC
PMID
41497795
PMCID
PMC12767591
DOI
10.1155/tbj/1035158

Abstract (original English)

Breast reconstruction post-mastectomy restores breast aesthetics and significantly enhances patients' self-confidence and psychological well-being. However, despite the effectiveness of current breast reconstruction techniques in restoring the aesthetic appearance of the breast, many patients continue to experience the loss of breast sensation following surgery, particularly the loss of nipple sensitivity, which significantly impacts postoperative quality of life. To address this issue, the use of nerve grafting techniques in breast reconstruction is increasingly being recognized and explored. This review summarizes the research progress of nerve grafting in breast reconstruction, highlighting its clinical applications, technical challenges, and future directions.

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

How we grade evidence
BreastNipplesHumansBreast NeoplasmsMammaplastyMastectomyFemale

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