SVF
Level D· Scientific groundwork from lab and animal studiesNarrative ReviewEurope PMCOpen access

Neuromodulation techniques for the treatment of spinal cord injury: current progress, challenges, and future prospects

Wenqiang L., Zhian C., Hua L., Yang L., Yi C., Zhijun C.

Narrative Review on Spinal Cord Injury, published in Eur J Med Res (2025) — summary generated from the PubMed abstract.

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Level D· Scientific groundwork from lab and animal studiesEvidence level of this study

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
Read the A–D evidence level guide

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Narrative Review
Journal
Eur J Med Res (2025)
Reported sample size
—
Source database
Europe PMC
PMID
40537873
PMCID
PMC12178020
DOI
10.1186/s40001-025-02689-y
Citations
3

Abstract (original English)

Spinal cord injury (SCI) is considered one of the key factors leading to severe loss of motor and sensory function, which has a profound negative impact on the quality of life of patients. With the continuous development of medical technology, neurostimulation techniques have gradually shown their importance in treating spinal cord injuries, demonstrating the potential for positive effects on functional recovery. Currently, various neurostimulation methods, including electrical stimulation, drug therapy, and biofeedback, have been employed in clinical research on spinal cord injury. Although we have achieved certain progress, there are still many unresolved mysteries regarding the performance and mechanisms of these technologies in actual clinical applications. At the same time, challenges such as individual differences and treatment efficacy evaluation also arise in clinical practice. This study aims to comprehensively review the latest research advancements in spinal cord injury neurostimulation technologies, explore their practical applications and related mechanisms in the process of functional recovery, and analyze potential future research directions, to provide innovative ideas and strategies for the treatment of spinal cord injuries.

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

How we grade evidence
HumansSpinal Cord InjuriesElectric Stimulation TherapyRecovery of Function
Back & SpineSpinal Cord Injury
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