Neuron-like cell differentiation of hADSCs promoted by a copper sulfide nanostructure mediated plasmonic effect driven by near-infrared light.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Nerve tissues are one of the most difficult tissues to repair due to the limited source of neural stem cells and the difficulty in promoting the neural differentiation of mesenchymal stem cells by growth factors. Electromagnetic field has been proved to have the ability to regulate stem cell differentiation. Although some research studies promoted the neural differentiation of stem cells using an external power source, it is still a big challenge to realize nerve repair in bodies because of the unwieldiness and complexity of the power supply equipment. Surface plasmons (SP) are electromagnetic oscillations caused by the interaction of free electrons and photons on a metal surface, and almost no one has used these localized electromagnetic oscillations to regulate stem cell differentiation. In this study, based on the concept proposed by our group that "the stem cell fate can be regulated by nanostructure mediated physical signals", the localized electromagnetic oscillation generated by the localized surface plasmon resonance (LSPR) of copper sulfide (CuS) nanostructures irradiated with near-infrared light has been proved to have positive regulation on stem cell maturation and neuron-like cell differentiation of human adipose-derived stem cells (hADSCs). This regulation method avoids the use of wire connection of an external power source, which realizes the stem cell fate regula

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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