Next-Generation Therapies for Gastrointestinal Repair: Converging Traditional Medicine and Tissue Engineering
Dhasmana A., Rautela I., Singh A., Santhanam A., Malik S., Govindarajan RK.
Narrative Review, published in JGH Open (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- JGH Open (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41416253
- PMCID
- PMC12710530
- DOI
- 10.1002/jgh3.70312
Abstract (original English)
The gastrointestinal (GI) tract plays a vital role in regulating metabolic pathways, nutrient absorption, and cellular homeostasis. Abnormalities in the GI tract often arise from unhealthy lifestyles, genetic mutations, and prolonged medication use, leading to disorders such as ulcers, cirrhosis, and malignancies. Conventional treatments including chemotherapy and surgery remain limited by high costs, invasiveness, and incomplete tissue recovery. Recent advances in bioengineering have enabled the development of grafts and drug-delivery systems that repair and regenerate functional GI tissue. This review presents a comprehensive overview of GI disorders, their current therapeutic options, and emerging tissue-engineering strategies that integrate regenerative medicine and traditional therapies to address metabolic and genetic dysfunctions.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
How we grade evidenceBrowse all related research
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