SVF
Level A· Stronger Clinical EvidenceSystematic Review

No evidence for the use of stem cell therapy for tendon disorders: a systematic review.

Pas HIMFL., Moen MH., Haisma HJ., Winters M.

Systematic Review with a reported sample of 5 on Osteoarthritis, Tendon Injury, Rotator Cuff, published in Br J Sports Med (2017) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Systematic Review
Journal
Br J Sports Med (2017)
Country
England
Reported sample size
5
PMID
28077355
DOI
10.1136/bjsports-2016-096794

Abstract (original English)

Stem cells have emerged as a new treatment option for tendon disorders. We systematically reviewed the current evidence for stem cell therapy in tendon disorders. Randomised and non-randomised controlled trials, cohort studies and case series with a minimum of 5 cases were searched in MEDLINE, CENTRAL, EMBASE, CINAHL, PEDro and SPORTDiscus. In addition, we searched grey literature databases and trial registers. Only human studies were included and no time or language restrictions were applied to our search. All references of included trials were checked for possibly eligible trials. Risk of bias assessment was performed using the Cochrane risk of bias tool for controlled trials and the Newcastle-Ottawa scale for case series. Levels of evidence were assigned according to the Oxford levels of evidence. 4 published and three unpublished/pending trials were found with a total of 79 patients. No unpublished data were available. Two trials evaluated bone marrow-derived stem cells in rotator cuff repair surgery and found lower retear rates compared with historical controls or the literature. One trial used allogenic adipose-derived stem cells to treat lateral epicondylar tendinopathy. Improved Mayo Elbow Performance Index, Visual Analogue Pain scale and ultrasound findings after 1-year follow-up compared with baseline were found. Bone marrow-derived stem cell-treated patellar tendinop

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

How we grade evidence
Cell- and Tissue-Based TherapyHumansKnee JointRandomized Controlled Trials as TopicRotator Cuff InjuriesStem CellsTendinopathy
KneeShoulderArm & ElbowOsteoarthritisTendon InjuryRotator Cuff
View on PubMedDOI

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