Novel Treatment of Pyramidal Multi-Type, Multi-Method, and Multi-Layer (3M) Autologous Fat Grafting Strategy for Infraorbital Aging.

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Lower eyelid aging manifests as several distinct issues, including tear trough deformities, eye bags (with or without skin laxity), and infraorbital dark circles. As lower eyelid aging represents a complex and multifactorial problem, the current approaches, relying on a single surgical technique or injection of single product, often yield unsatisfactory results. The present study describes a simplified strategy utilizing fat derivatives transplantation: the Pyramidal Multi-type, Multi-method, and Multi-layer (3M) strategy. This approach achieved favorable outcomes by simultaneously addressing all these lower eyelid aging problems. Methods This study included 53 patients (106 sides), with a median follow-up of 15.5 months (range from 6 to 24 months). All patients received Pyramidal 3M fat grafting for lower eyelid aging by deep transplantation of macrofat, superficial transplantation of microfat or microfat/superficial enhanced fluid fat (SEFF), and subdermal transplantation of nanofat or stromal vascular fraction (SVF). We retrospectively analyzed the histories and photographs of patients who underwent Pyramidal 3M fat grafting for lower eyelid aging. Patients were followed up before and 6 months after the treatments by modified Goldberg scale and subject satisfaction assessment (SSA) scale. Results Only mild adverse effects such as mild edema and transient ecchymosi

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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