Nucleic acid-based therapeutics to restore joint homeostasis in age-related and post-traumatic arthritis

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Osteoarthritis, a complex genetic disease, involves disrupted joint homeostasis driven by catabolic and inflammatory processes. Traditional therapies offer limited success. This review explores nucleic acid-based therapeutics-siRNA, miRNA, and mRNA-as a promising strategy for restoring balance by modulating gene expression. Nanoplatforms enable precise delivery of these molecules, offering potential for disease-modifying interventions. Emphasis is placed on advancing RNA therapies tailored to the disease stage for effective disease management.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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