Omics characteristics and epigenetic modifications of adipose-derived stem cells.
Feng T., Rosen CJ., Li Z.
Narrative Review, published in J Biol Chem (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- J Biol Chem (2025)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41005477
- PMCID
- PMC12590281
- DOI
- 10.1016/j.jbc.2025.110758
Abstract (original English)
Adipose-derived stem cells (ADSCs) possess multipotency to differentiate into various lineages, including adipocytes, osteoblasts, neurons, and smooth muscle cells, thereby demonstrating significant potential in tissue regeneration. Recent advances in omics technologies have enhanced our understanding of ADSC molecular profiles by transcriptomic, proteomic and lipidomic analysis. Additionally, epigenetic modifications, which mediate heritable changes in gene expression without altering the DNA sequence, play a pivotal role during the multiple lineage differentiation of ADSC. This review presents a summary of recent findings on ADSC omics and epigenetics, offering an updated perspective on their distinct attributes.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
How we grade evidenceBrowse all related research
Filter the research library by this study's title keywords, author, or publication year.