Optimization of autologous adipose tissue transplantation: The impact of patient-specific and intraoperative factors on cellular viability before and after cryopreservation.
Pinto V., Taccioli F., Benivegna D., Kaleci S., De Santis G., Pinelli M.
Retrospective Study with a reported sample of 55, published in J Plast Reconstr Aesthet Surg (2025) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Retrospective Study
- Journal
- J Plast Reconstr Aesthet Surg (2025)
- Country
- Netherlands
- Reported sample size
- 55
- Source database
- PubMed
- PMID
- 40753044
- DOI
- 10.1016/j.bjps.2025.06.049
- Citations
- 2
Abstract (original English)
Background Autologous adipose tissue transplantation is a versatile surgical procedure used for aesthetic, reconstructive, and regenerative purposes. Cryopreservation of adipose tissue collected during liposuction reduces the need for repeated fat collection, minimizing patient discomfort while preserving volumetric and regenerative properties. There are currently no studies in the literature correlating cellular viability, before and after thawing, with patient-specific variables and collection techniques. This study investigates patient-specific factors affecting cellular viability before and after thawing to refine protocols for patient selection and tissue collection. Materials and methods A retrospective analysis of 55 patients from the University Hospital Policlinico of Modena was conducted. Intraoperative factors (disinfectant used, type of anesthesia, operators, associated procedure, duration of surgery, harvesting area, quantity collected) and clinical variables (age, sex, smoking status, comorbidities, antiblastic therapy, hormonal therapy, radiation therapy, immunological therapy) were analyzed. Cell count and metabolic activity tests were performed pre- and post-cryopreservation. Results Hormonal therapy significantly correlates with reduced cellular metabolic activity and viability, both pre- and post-thawing. Conclusions The findings underscore the need to evaluat
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • Without an adequate control group, treatment effects cannot be separated from other factors.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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