Orthobiologics for Cartilage Repair.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Orthobiologics are substances derived from biological sources and are increasingly used in cartilage repair. Mesenchymal signaling cells (MSCs) play a crucial role in cartilage regeneration, but face challenges in clinical application. Platelet-rich plasma, concentrated bone marrow aspirate, adipose tissue, and human umbilical cord blood have all demonstrated potential as sources for MSCs and growth factors necessary for cartilage repair. Existing cartilage repair techniques have shown good outcomes with additional orthobiologic augmentation. Emerging techniques involving third-generation and fourth-generation matrix-induced autologous chondrocyte implantation, decellularized or cryopreserved osteochondral grafts, and artificial scaffolds have demonstrated promising results long-term with cartilage repair procedures.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.