[Osteoarthritis and cellular therapeutics].

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Osteoarthritis, a degenerative disorder of the osteoarticular system, leads to progressive cartilage deterioration, resulting in pain and functional impairment. Its clinical presentation is heterogeneous, reflecting a diversity of phenotypes and molecular profiles. Risk factors include advanced age, female sex, obesity and joint trauma. Among emerging therapeutic strategies, mesenchymal stem cells (MSCs) offer promising prospects. These cells, derived from bone marrow, adipose tissue, and umbilical tissues, exhibit regenerative and immunomodulatory properties. In parallel, MSC-derived exosomes, which carry regenerative bioactive factors, represent another avenue of innovation, though their clinical application still requires further validation. L’arthrose, pathologie dégénérative du système ostéo-articulaire, provoque une détérioration du cartilage, générant douleurs et incapacités fonctionnelles. Sa présentation clinique, polymorphe, découle de multiples phénotypes et profils moléculaires. Les facteurs de risque incluent l’âge avancé, le sexe féminin, l’obésité et les traumatismes articulaires. Parmi les thérapeutiques innovantes, les cellules souches mésenchymateuses (CSM) offrent des perspectives prometteuses. Ces cellules, dérivées de la moelle osseuse, du tissu adipeux et de tissus ombilicaux, présentent des propriétés régénératrices et immunomodulatrices. En parallèle, le

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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