Osteogenic Differentiation Triggered by Intracellular Magnetoelectric Stimulation of Core-Shell Nanotransducers under Remotely Applied Magnetic Fields.
Mendes MC., Martins EAG., Chernozem RV., Chernozem PV., Custódio CC., Surmenev RA.
Laboratory Study, published in ACS Nano (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- ACS Nano (2025)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41347717
- PMCID
- PMC12818836
- DOI
- 10.1021/acsnano.5c10509
Abstract (original English)
Magnetoelectric nanoparticles (MENPs), combining a magnetostrictive core with a piezoelectric shell, offer a promising route for remote-controlled biomedical applications by converting external magnetic fields into electric cues. However, the clinical translation of these materials remains limited due to the toxicity of high-performance piezoelectric materials, which typically contain lead. Previously, we developed lead-free MENPs comprising manganese ferrite oxide (MFO) core nanoparticles (NPs) coated with a Ba 0.85 Ca 0.15 Zr 0 . 1 Ti 0.9 O 3 (BCZT) piezoelectric shell (MFO@BCZT). While these nanotransducers exhibit robust magnetic responsiveness and piezoelectric performance comparable to lead-based ceramics, their role in producing in situ electrical cues to accelerate bone repair remains unexplored. Given the established role of electrical stimulation in bone remodeling, this study explores the potential of MFO@BCZT MENPs to promote the osteogenic differentiation of human adipose-derived stem cells (hASCs) after internalization, assembly into magnetized 3D spheroids, and subsequent embedding in gelatin methacryloyl hydrogels, to better recapitulate physiologically relevant microenvironments. Differentiation was assessed under static and cyclic magnetic field (CMF) conditions and compared to spheroids containing bare MFO NPs and spheroids without NPs. Results revealed that
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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