Oxidative homeostasis and survival instincts of chicken egg, embryo and adult
Ali MA., Niaz MK., Song JZ., Sun HY., Niu YJ., Zuo QS.
Narrative Review, published in Poult Sci (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Poult Sci (2026)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41846085
- PMCID
- PMC13010960
- DOI
- 10.1016/j.psj.2026.106710
- Citations
- 1
Abstract (original English)
Chicken embryos and stem cells require precisely regulated levels of reactive oxygen species (ROS) to maintain self-renewal and pluripotency. However, excessive ROS induces oxidative stress, leading to DNA damage, chromosomal aberrations, loss of mitochondrial membrane potential, and ultimately, abnormal differentiation or cell death. This oxidative imbalance is a significant barrier to successful embryonic development and the in vitro culture of stem cells. Innate antioxidant defense systems exist within chicken and mammalian embryos to scavenge excess ROS, a finding that has prompted the strategic addition of antioxidants to culture media. The present review has two primary foci. Firstly, it seeks to expand the understanding of the antioxidant defense mechanisms of the chicken embryo. Secondly, it explores the role of exogenous antioxidant supplementation in the culture of various stem cell types, including embryonic stem cells (ESCs), primordial germ cells (PGCs), spermatogonial stem cells (SSCs), and induced pluripotent stem cells (iPSCs). Enhancing in vitro stem cell survival and directed differentiation through antioxidant supplementation holds significant promise for advancing fields such as tissue regeneration, organ transplantation, and the development of transgenic chicken models for improved production traits, vaccine development, and recombinant protein production.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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