PAF signaling plays a role in obesity-induced adipose tissue remodeling.
Costa KA., Lacerda DR., Silveira ALM., Martins LB., Oliveira MC., Rezende BM.
Prospective Study, published in Int J Obes (Lond) (2021) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Prospective Study
- Journal
- Int J Obes (Lond) (2021)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 34493775
- DOI
- 10.1038/s41366-021-00961-9
- Citations
- 6
Abstract (original English)
Background/objectives Platelet-activating factor receptor (PAFR) activation controls adipose tissue (AT) expansion in animal models. Our objective was twofold: (i) to check whether PAFR signaling is involved in human obesity and (ii) investigate the PAF pathway role in hematopoietic or non-hematopoietic cells to control adipocyte size. Materials/subjects and methods Clinical parameters and adipose tissue gene expression were evaluated in subjects with obesity. Bone marrow (BM) transplantation from wild-type (WT) or PAFR -/- mice was performed to obtain chimeric PAFR-deficient mice predominantly in hematopoietic or non-hematopoietic-derived cells. A high carbohydrate diet (HC) was used to induce AT remodeling and evaluate in which cell compartment PAFR signaling modulates it. Also, 3T3-L1 cells were treated with PAF to evaluate fat accumulation and the expression of genes related to it. Results PAFR expression in omental AT from humans with obesity was negatively correlated to different corpulence parameters and more expressed in the stromal vascular fraction than adipocytes. Total PAFR -/- increased adiposity compared with WT independent of diet-induced obesity. Differently, WT mice receiving PAFR -/- -BM exhibited similar adiposity gain as WT chimeras. PAFR -/- mice receiving WT-BM showed comparable augmentation in adiposity as total PAFR -/- mice, demonstrating that PAFR sign
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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