Percutaneous Aponeurotomy Combined with Autologous Fat Grafting for Early Dupuytren's Disease.
Bülbüloğlu İ., Tuncel U., Öztürk DC., Bilgiç B., Sönmez A., Ünaldı I.
Prospective Study with a reported sample of 57, published in Aesthetic Plast Surg (2026) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Prospective Study
- Journal
- Aesthetic Plast Surg (2026)
- Country
- United States
- Reported sample size
- 57
- Source database
- PubMed
- PMID
- 41973231
- DOI
- 10.1007/s00266-026-05824-0
Abstract (original English)
Percutaneous needle aponeurotomy (PNA) is a well-established minimally invasive technique for treating early-stage Dupuytren's disease; however, recurrence remains a concern. Recent studies have suggested that autologous fat grafting may have regenerative and antifibrotic effects, potentially improving clinical outcomes when combined with minimally invasive techniques. In this current study, 57 patients with Tubiana stage 1-3 Dupuytren's disease were treated with PNA combined with autologous fat grafting between 2022 and 2024. Fat was harvested from the abdomen and processed via the cotton gauze rolling technique. Joint contractures were evaluated preoperatively and at 1 and 12 months postoperatively. Postoperative recovery time, complication rates, and recurrence were also analyzed. Significant improvements were observed in both MCP and PIP joint contractures at 1 and 12 months (p < 0.001). The mean follow-up was 17.4 ± 3.4 months. No clinical recurrences were noted. Only 7% of patients experienced minor, self-limiting complications. Most patients resumed daily activities within one week postoperatively. PNA combined with autologous fat grafting offers a safe, effective, and biologically favorable approach for managing early-stage Dupuytren's disease. The technique promotes rapid recovery, minimizes complications, and may reduce recurrence through adipose tissue's regenerative
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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