Peri-prosthetic Fat Grafting Decreases Collagen Content, Density, and Fiber Alignment of Implant Capsules
Komorowska-Timek E., Jaźwiec A., Adams NS., Fahrenkopf MP., Davis AT.
Laboratory Study, published in Plast Reconstr Surg Glob Open (2021) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Plast Reconstr Surg Glob Open (2021)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 35028254
- PMCID
- PMC8751766
- DOI
- 10.1097/gox.0000000000003687
- Citations
- 6
Abstract (original English)
Background Lower capsular contracture rates have been observed with peri-prosthetic fat grafting. We investigated the effect of fat grafting on capsular characteristics and peri-prosthetic collagen density, content, and fiber alignment. Methods Forty miniature tissue expanders were placed on the backs of 20 rats. After four weeks, both inguinal fat pads were harvested, homogenized, and injected into peri-prosthetic tissue of the right tissue expander (fat graft) while the left served as control. The animals were killed at three (10 rats) and 12 weeks (10 rats), and full thickness peri-prosthetic samples were histologically processed for morphology (H&E) and collagen type and content (picrosirius red). Results An 8.1% increase in adipose peri-prosthetic thickness was associated with a 10% decrease in collagen content at any time point ( P = 0.004). Fat-grafted capsules displayed a 59% reduction in % total collagen when compared with controls ( P P 0.001 and P = 0.001, respectively). The extent of inflammation decreased over time in all samples ( P = 0.002). Additionally, fat-grafted samples were 67 times more likely to have a lower fiber alignment score than the controls ( P 0.001). Conclusions Enhancement of peri-prosthetic tissue with fat grafting decreases collagen content, density, and fiber alignment of implant capsules. These findings support clinical application of fat gr
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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