Permanent Facial Fillers: Addressing Complications and Advancing Solutions.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Soft tissue augmentation with fillers has witnessed a surge in popularity for rejuvenating facial features, offering solutions for wrinkles, volume loss, and contour irregularities. Non-biodegradable fillers like silicone, polyacrylamide hydrogel, and polymethylmethacrylate (PMMA) have been introduced, promising enduring results. However, reports on silicone filler usage have highlighted a spectrum of adverse events, ranging from erythema and edema to more severe complications like infection, vascular occlusion, and inflammatory nodules. The adverse effects of non-resorbable facial fillers can manifest even years post-procedure, resulting in significant discomfort and dissatisfaction for patients. Consequently, the literature is focusing on potential treatments for these outcomes, including systemic antibiotics, corticosteroid injections, surgical drainage, and excision. Despite these options, consensus on optimal treatment modalities remains elusive. Surgical excision is the definitive method for removing permanent fillers, albeit with the risk of post-removal irregularities. Fat grafting has emerged as a viable solution, allowing for the correction of volume deficits and asymmetries. Utilizing the patient's own tissue, fat grafting reduces the risk of adverse reactions and rejection. It offers targeted volume enhancement, restoring facial symmetry and proportion, and promotin

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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