Physiological Oxygen Levels Differentially Regulate Adipokine Production in Abdominal and Femoral Adipocytes from Individuals with Obesity Versus Normal Weight.
Lempesis IG., Hoebers N., Essers Y., Jocken JWE., Rouschop KMA., Blaak EE.
Laboratory Study with a reported sample of 9, published in Cells (2022) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Cells (2022)
- Country
- Switzerland
- Reported sample size
- 9
- Source database
- PubMed
- PMID
- 36428961
- PMCID
- PMC9688196
- DOI
- 10.3390/cells11223532
- Citations
- 7
Abstract (original English)
Adipose tissue (AT) inflammation may increase obesity-related cardiometabolic complications. Altered AT oxygen partial pressure (pO 2 ) may impact the adipocyte inflammatory phenotype. Here, we investigated the effects of physiological pO 2 levels on the inflammatory phenotype of abdominal (ABD) and femoral (FEM) adipocytes derived from postmenopausal women with normal weight (NW) or obesity (OB). Biopsies were collected from ABD and FEM subcutaneous AT in eighteen postmenopausal women (aged 50-65 years) with NW (BMI 18-25 kg/m 2 , n = 9) or OB (BMI 30-40 kg/m 2 , n = 9). We compared the effects of prolonged exposure to different physiological pO 2 levels on adipokine expression and secretion in differentiated human multipotent adipose-derived stem cells. Low physiological pO 2 (5% O 2 ) significantly increased leptin gene expression/secretion in ABD and FEM adipocytes derived from individuals with NW and OB compared with high physiological pO 2 (10% O 2 ) and standard laboratory conditions (21% O 2 ). Gene expression/secretion of IL-6, DPP-4, and MCP-1 was reduced in differentiated ABD and FEM adipocytes from individuals with OB but not NW following exposure to low compared with high physiological pO 2 levels. Low physiological pO 2 decreases gene expression and secretion of several proinflammatory factors in ABD and FEM adipocytes derived from individuals with OB but not NW.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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