Piezoelectric PCL/PVDF core-shell nanofibrous scaffolds for enhanced osteogenesis under dynamic loading.
Asadi G., Katbab AA., Bagheri-Khoulenjani S., Haghighipour N.
Laboratory Study, published in Biomater Adv (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Biomater Adv (2026)
- Country
- Netherlands
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 42035697
- DOI
- 10.1016/j.bioadv.2026.214888
Abstract (original English)
Biomimetic tissue engineering scaffolds must recapitulate the specific structural, biochemical, and electromechanical properties of the native extracellular matrix (ECM) to support cellular function and tissue regeneration. Bone exhibits piezoelectricity, converting mechanical stress into electrical signals that regulate mechanotransduction and guide its remodeling. Likewise, piezoelectric scaffolds can replicate this native ECM feature, providing mechanical support and bioactive stimuli that promote cell growth and differentiation. To develop a suitable bone scaffold with desirable mechanical, biological, and piezoelectric properties, a core-shell nanofibrous scaffold consisting of PCL-PVDF (Polycaprolactone-Polyvinylidene fluoride) and PCL-PVDF-HA (Hydroxyapatite-incorporated) fibers (PVDF or PVDF-HA as shell) was fabricated through coaxial electrospinning. Scanning electron microscopy (SEM) was used to investigate the microstructural characteristics, and images of fractured fiber cross-sections confirmed the successful formation of the core-shell morphology. Piezoelectric properties were initially characterized by XRD and ATR-FTIR, and further validated by measuring the output voltage with an oscilloscope. The core-shell PCL-PVDF scaffold exhibited the highest piezoelectric response compared to the neat PCL, neat PVDF, and PCL-PVDF-HA fibers. The effect of mechanically induc
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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